姓名:葛亚东

职称:副教授

电话:0553-3868082 (O)

邮箱:geyd@ahnu.edu.cn

主要学习工作经历

200220052010 安徽师范大学分别获学士、硕士、博士学位

2002年至今 安徽师范大学365体育亚洲登录平台工作,历任讲师、副教授

2012 美国堪萨斯州立大学从事博士后研究工作

2018年至今 安徽师范大学国际教育学院副院长(兼国际交流合作处副处长)

主要社会兼职

安徽省外国留学生教育管理学会 理事

主要研究内容

蛋白质酶学与功能演化

蓝藻关键代谢酶基因功能

主要研究课题

国家自然科学基金项目不同克隆轮虫形态可塑性差异及其生态学与分子生物学机制研究(32070463)2021-2024第一参与

国家自然科学基金项目铜绿微囊藻苹果酸脱氢酶的酶学及辅酶特异性转换研究(31300006)2014-2016,主持

安徽省自然科学基金项目铜绿微囊藻苹果酸脱氢酶的结构与辅酶进化关系研究(1208085QC52)2012-2014,主持

安徽省高等学校优秀青年人才基金项目链霉菌基因组文库构建及工业用酶基因的筛选与改造(2009SQRZ030)2009-2011,主持

主要研究成果

一、代表性论文及论著

1. Ge Yadong*, Guo Yitian, Jiang Lulu, Wang Huihui, Hou Shaolin, Su Fengzhi. Enzymatic characterization and coenzyme specificity conversion of a novel dimeric malate dehydrogenase from Bacillus subtilis. The Protein Journal, 2023, 42(1): 14-23.

2. Ge Yadong*, Jiang Lulu, Hou Shaolin, Su Fengzhi, Wang Peng, Zhang gen*. Heteroexpression and biochemical characterization of thermostable citrate synthase from the cyanobacteria Anabaena sp. PCC7120. Protein expression and purification, 2020, 168:e105565.

3. Ge Yadong*, Hou Shaolin, Jiang Lulu, Su Fengzhi, Wang Peng. Expression and characterization of a thermostable citrate synthase from Microcystis aeruginosa PCC7806. FEMS microbiology letters. 2019, 366(19):e1-7.

4. Ge Yadong, Cao Zhengyu, Song Ping, Zhu Guoping*. Identification and characterization of a novel citrate synthase from Streptomyces diastaticus No.7 strain M1033. Biotechnology and Applied Biochemistry, 2015, 62(3):300-308.

5. Ge Yadong, Song Ping, Wang Peng, Zhu Guoping*. Alteration of coenzyme specificity of malate dehydrogenase from Streptomyces coelicolor A3(2). Genetics and Molecular Research,2014, 13(3):5758-5766.

6. Ge Yadong, Cao Zhengyu, Wang Zongda, Chen Lulu, Zhu Youming, Zhu Guoping*. Identification and biochemical characterization of a thermostable malate dehydrogenase from the mesophile Streptomyces coelicolor A3(2). Bioscience Biotechnology and Biochemistry, 2010, 74 (11):2194-2201.

7. Li Xue, Wang Peng, Ge Yadong, Wang Wen, Abbas Abdulla, Zhu Guoping*. NADP+-specific isocitrate dehydrogenase from oleaginous yeast Yarrowia lipolytica CLIB122: biochemical characterization and coenzyme sites evaluation. Applied Biochemistry Biotechnology, 2013, 171:403-416.

8. Wang Zongda, Wang Baojuan, Ge Yadong, Pan Wei, Wang Jie, Xu Lei, Liu Aimin, Zhu Guoping*. Expression and identification of a thermostable malate dehydrogenase from multicellular prokaryote Streptomyces avermitilis MA-4680. Molecular Biology Reports, 2011, 38:1629-1636.

9. Zhao Hanjun, Wang Peng, Huang Enqi, Ge Yadong, Zhu Guoping*. Physiologic roles of soluble pyridine nucleotide transhydrogenase in Escherichia coli as determined by homologous recombination. Annals of Microbiology, 2008, 58(2):275-280.

10. 葛亚东, 葛雅丽, 王鹏, 朱国萍*. 分子生物学国家级双语教学示范课程的实践与思考. 中国细胞生物学学报, 2013, 35(8): 1251-1254.

11. 葛亚东, 葛雅丽. 浅谈对分子生物学教学改革的几点认识. 安徽农学通报, 2013, 19(03):154-155.

12. 葛亚东, 潘蔚, 汪诘, 朱国萍*. 柠檬酸合酶的分子生物学研究进展. 生物学杂志, 2010, 27(3): 59-62.

 

二、授权专利:

    一种热稳定性苹果酸脱氢酶基因的构建方法、编码蛋白及其应用,中国发明专利号:ZL 2019 1 0900263.02021